Abstract
The Gen3 Kidney Organ-on-a-Chip (OOC) project aims to revolutionize preclinical drug testing through a modular, scalable, and automation-ready platform focused on complex human kidney model. Utilizing injection molding for cost-effective and reproducible manufacturing, the dual-channel microfluidic chip features cylindrical nephron tubule channels that replicate in vivo shear forces and support advanced biological modeling, including drug delivery and multi-cellular interactions. The system integrates seamlessly with high-throughput automation platforms and leverages AI/ML tools to analyze imaging and sensor data for real-time optimization. By addressing limitations in current OOC systems—such as high costs, limited scalability, and suboptimal physiological accuracy—this project delivers an innovative, sustainable, and cost-effective solution for pharmaceutical and academic research. With rising number of drugs discovered by AI driven systems, the need for a physiologically relevant, scalable system for drug screening becomes imminent. This project aligns with the EU Directive 2010/63 on the protection of animals used for scientific purposes, which enshrines the 3Rs (Replace, Reduce, Refine), and with the FDA’s modernization acts 2.0, 3.0.
Consortium

COORDINATOR

  Quris technologies LTD

Shachar Gal

PARTNERS

Quris technologies LTD

MILDENDO mbH