Flood cooling, using an emulsion of oil in water, is commonly used in machining operations of ‘difficult-to-machine’ materials (e.g. titanium alloys) to break the downward tool wear spiral caused by excessive heat and in machining operations of ‘high-stick’ materials (e.g. aluminum alloys) to limit tool blunting. Novel cooling fluids that operate at sub-zero temperatures, such as liquid nitrogen (LN2) and carbon dioxide (CO2), have superior cooling capacities and are environmentally friendly since they are a natural part of our atmosphere. However, these cooling fluids come along with considerable challenges, from coolant storage up to end product quality and every step in between, that need to be addressed in order to achieve a successful industrial implementation. Within the CryoMach project research will be performed on the coolant delivery system including a tool holder with internal cooling capacity, a simulation model and process window for a selected group of operations and materials and the influence of the cryogenic coolant on machine tool and machined component. Based upon state-of-the-art research prototype installations for cutting tests in turning, milling and drilling will be developed.